Saint James of Jerusalem received martyrdom in AD 63 and Jerusalem subsequently spun into the First Jewish-Roman War. The Jewish Christians under the leadership of James' successor, Saint Simeon fled Jerusalem in obedience to Christ's warning. Meanwhile Nero (the man of "666) is madly killing Christians in Rome, including Saints Peter and Paul.
In AD 70, the Romans sacked Jerusalem and destroyed the Temple and brought about the "end of the [Mosaic] age".
Might we say that the murder of James of Jerusalem in AD 63 kicks of the microcosmic "seven year tribulation"?
This by now means denies a future tribulation. The close of the Jewish age is typological of the close of the temporal age.
For other related topics listen to The Mark of the Beast and Caesar Podcast by Taylor Marshall.